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1 “Study provides first estimate of U.S. population affected by Barrett’s esophagus.” Gastro.org. 2006. American Gastroenterological Association. Accessed August 2007.

2 Reid B.J and Weinstein W. M. Barrett's esophagus and adenocarcinoma. Gastroenterology Clinics of North America 1987; 38: 477-492.

3 "What Are the Key Statistics about Cancer of the Esophagus?" Cancer.org. 2006. American Cancer Society. Accessed October 2007.

4 Shaheen N, Ransohoff DF. Gastroesophageal reflux, Barrett’s esophagus and esophageal cancer. Journal of the American Medical Association. 2002; 287: 1972-1981.

5 Westhoff B, Brotze S, Weston A, et al. The frequency of Barrett’s esophagus in high-risk patients with chronic gerd. Gastrointestinal Endosc. 2005; 61:226-231.

6 Ganz RA, Utley DS, Stern RA, et al. Complete ablation of esophageal epithelium with a balloon-based bipolar electrode: a phased evaluation in the porcine and in the human esophagus. Gastrointest Endosc 2004; 60:1002-10.

7 Sharma VK, Wang KK, Overholt BF, et al. Balloon-based, circumferential, endoscopic radiofrequency ablation of Barrett’s esophagus: 1-year follow-up of 100 patients. Gastrointest Endosc 2007; 65:185-194.

8 Fleischer DE, Overholt BF, Sharma VK, et al. Long-term (2.5 year) follow-up of the AIM-II trial for ablation of Barrett esophagus: results after primary circumferential ablation followed by secondary focal ablation. Gastrointest Endosc 2007; 65: AB 135.

9 Gerson LB, Shetler K, and Triadafilopoulos G. Prevalence of Barrett’s esophagus in asymptomatic individuals. Gastroenterology 2002;123:461-467

10 “Fastest Rising Form of Cancer in the U.S.” Webmd.com. 2005. WebMD. www.webmd.com/cancer/news/20050118/esophageal-cancer-on-rise  Accessed October 2007.

11 http://www.barrettsinfo.com/content/3c_what_is_dysplasia.htm.

12 Sharma P, Falk GW, Weston AP, Reker D, Johnston M, Sampliner RE. Dysplasia and Cancer in a Large Multicenter Cohort of Patients with Barrett’s Esophagus. Clinical Gastroenterology and Hepatology 2006;4:566-572.

13 John Hopkins Pathology website, http://pathology2.jhu.edu/beweb/menu_understanding.cfm.

14 Data on file

15 http://www.barrx.com/Healthcare_Professionals/index.cfm/43

16 Heiko Pohl and H.G. Welch. The role of over diagnosis and reclassification in the Marked Increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst. 2005: 97: 142-146.

17 G.M. Eisen. Ablation therapy for Barrett's esophagus. Gastrointestinal Endosc. 2003; 58: 760-769.

18 "What Are the Key Statistics about Cancer of the Esophagus?" Cancer.org. 2006. American Cancer Society. Accessed October 2007.

19 Sharma VK, Kim HJ, Musil D, Crowell MD, et al. Circumferential ablation of Barrett's esophagus with low-grade dysplasia: One and two year follow-up of the AIM-LGD Trial. Gastrointest Endosc. 2007; 65: AB155.

20 Pouw RE, Wirths K, Eisendrath P, et al. Efficacy of radiofrequency ablation combined with endoscopic resection for Barrett’s esophagus with early neoplasia. Clin Gastroenterol Hepatol 2010;8:23-29.

21 Pouw RE, Gondrie JJ, Sondermeijer CM, et al. Eradication of Barrett esophagus with early neoplasia by radiofrequency ablation, with or without endoscopic resection. J Gastrointest Surg 2008;12:1627-1636.

22 Lyday WD, Corbett FS, Kuperman DA, et al. Radiofrequency ablation of Barrett's esophagus: outcomes of 429 patients from a multicenter community practice registry. Endoscopy 2010;42:272-278.

23 Wani S, Puli SR, Shaheen NJ, Westhoff B, Slehria S, Bansal A, Rastogi A, Sayana H, Sharma P. Esophageal adenocarcinoma in Barrett's esophagus after endoscopic ablative therapy: a meta-analysis and systematic review. Am J Gastroenterol. 2009 Feb;104(2):502-13.

24 Curvers WL, ten Kate FJ, Krishnadath KK, Visser M, Elzer B, Baak LC, Bohmer C, Mallant-Hent RC, van Oijen A, Naber AH, Scholten P, Busch OR, Blaauwgeers HG, Meijer GA, Bergman JJ. Low-grade dysplasia in Barrett's esophagus: overdiagnosed and underestimated. Am J Gastroenterol. 2010 Jul;105(7):1523-30.

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26 Fleischer DE, Overholt BF, Sharma VK, et al. Endoscopic Radiofrequency Ablation for Barrett’s Esophagus: Five-Year Durability Outcomes from a Prospective Multi-Center Trial. Gastrointest Endosc 2010;71:AB117-118.

27 Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esophagus in the general population: an endoscopic study. Gastroenterology 2005; 129:1825-1831.

28 Sharma VK, Kim HJ, Das A, et al. A prospective pilot trial of ablation of Barrett's esophagus with low-grade dysplasia using stepwise circumferential and focal ablation (HALO system). Endoscopy 2008;40:380-387.

29 Pouw RE, Gondrie JJ, Rygiel AM, et al. Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia. Am J Gastroenterol 2009 Jun;104:1366-1373.

30 Beaumont H, Gondrie JJ, McMahon BP, et al. Stepwise radiofrequency ablation of Barrett's esophagus preserves esophageal inner diameter, compliance, and motility. Endocopy 2009;41:2-8.

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